図7. 抗てんかん薬

Column: ReproSil-Pur C18-AQ, 120Å, 5µm, 250×3mm
Guard column: ReproSil DIBS, 12µm, 13×4mm
Sample: Antiepileptic as integrated sample injection
(serum with added metabolites)
1 = PEMA (5.2ng/ml)
2 = Ethosuximide (153.8ng/ml)
3 = Primidone (6.4ng/ml)
4 = Lamotrigine (10.4ng/ml)
5 = Carbamazepindiol (1.6ng/ml)
6 = 10-OH-Carbamazepine
7 = Phenobarbital (6.8ng/ml)
8 = Desmethylmesuximide (2.6ng/ml)
9 = Carbamazepinepoxide (9.8ng/ml)
10 = Oxycarbamazepine
11 = Phenytoine (3.9ng/ml)
12 = Carbamazepine (10.2ng/ml)
Eluent A: 0.2M K2PO4 + 1% MeOH
Eluent B: 50mM K2PO4/MeOH/ACN : 300/125/75
Gradient: 0 -100% B in 40min
Flow rate: 0.4ml/min